Identification and characterization of a novel unknown glycosyltransferase GTUF in breast cancer cells
| Project/Area Number |
25860240
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Iwate Medical University (2014)
The University of Tokushima (2013) |
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Principal Investigator |
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| Research Collaborator |
KATAGIRI Toyomasa 徳島大学, 疾患プロテオゲノム研究センター, 教授 (60291895)
ONO Masaya 国立がんセンター研究所, 化学療法部, 室長 (00270900)
MIYOSHI Yasuo 兵庫医科大学, 医学部, 教授 (50283784)
BANDO Yoshimi 徳島大学病院, 准教授 (00238239)
SASA Mitsunori とくしまブレストケアクリニック
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乳癌 / 糖転移酵素 |
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| Outline of Final Research Achievements |
In this study, we report the critical role of an unknown glycosyltransferase GTUF (GlycosylTransferase of Unknown Function) in breast cancer cells. Although GTUF was frequently up-regulated in breast cancer cells, including triple negative breast cancer (TNBC) cells, it was not significantly expressed in normal tissues. Knockdown of GTUF by siRNA significantly suppressed cell growth and induced apoptosis in both TNBC and non-TNBC cells. GTUF has two glycosylated sites and its glycosylation is important for secretion into culture medium from cells. These results suggested that GTUF might be a novel therapeutic target and molecular marker of breast cancer.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.2013
Author(s)
Yoshimaru T, Komatsu M, Matsuo T, Chen YA, Murakami Y, Mizuguchi K, Mizohata E, Inoue T, Akiyama M, Yamaguchi R, Imoto S, Miyano S, Miyoshi Y, Sasa M, Nakamura Y, Katagiri T.
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Journal Title
Nature Communications
Volume: 4
Pages: 2443-2443
Related Report
Peer Reviewed
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