| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The liver X receptor (LXR) plays a role in regulation of cholesterol homeostasis. LXR is also involved in inflammation and immunity. However, a role of LXR in liver immune cells remains unclear. In this study, we investigated effects of LXR on distribution and function of mouse hepatic mononuclear cells. As compared with wild-type mice, the total cell number and the proportion of bone marrow derived macrophages were increased in the liver of LXR-deficient mice. Proinflammatory cytokine production induced by lipopolysaccaride was also enhanced in LXR-deficient mice. On the other hand, the proportion of hepatic natural killer T cells was decreased and their cytokine production capacity was defected in LXR-deficient mice. We showed that LXR may be an important mediator that regulates hepatic immune cell population and cytokine production.
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