Screening of Alzheimer's desease therapeutic targets based on neprilysin life cycle

Research Project

Project/Area Number	25860251
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pathological medical chemistry
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	KAKIYA NAOMASA 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (20383903)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	アルツハイマー病 / ネプリライシン
Outline of Final Research Achievements	I have already shown a regulatory mechanism in neprilysin localization dependent on phosphorylation and dephosphorylation. While, I also found out the possibility that phosphorylation of neprilysin may be involved in the metabolism and allosteric activation. In this study, I succeed to reveal the relationship between neprilysin phosphorylation and metabolism.

Report

(3 results)