Screening of Alzheimer's desease therapeutic targets based on neprilysin life cycle
| Project/Area Number |
25860251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KAKIYA NAOMASA 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (20383903)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルツハイマー病 / ネプリライシン |
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| Outline of Final Research Achievements |
I have already shown a regulatory mechanism in neprilysin localization dependent on phosphorylation and dephosphorylation. While, I also found out the possibility that phosphorylation of neprilysin may be involved in the metabolism and allosteric activation. In this study, I succeed to reveal the relationship between neprilysin phosphorylation and metabolism.
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Report
(3 results)
Research Products
(3 results)
