Elucidation of chemokine network associated with lung adenocarcinoma progression
Project/Area Number |
25860272
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Yokohama City University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ケモカイン / 肺腺癌 / 悪性化 / サイトカイン |
Outline of Final Research Achievements |
In the course of searching downstream molecules of KRAS induction, the chemokines were focused, and expression analysis of the genes was performed. Some of the lung cancer cell lines showed complete loss of CXCL7 mRNA expression. The mRNA expression of CXCL7 and CXCR2 in clinical samples were positively correlated. The expression of CXCL7 was observed in poorly differentiated adenocarcinoma. Some cases revealed strong expression of CXCL7 in cancer cells accompanied by prominent lymphocytic infiltration. These data suggest chemokines are involved in lung adenocarcinoma progression and cancer microenvironment.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] 肺腺癌におけるIL24の発現解析2014
Author(s)
梅田茂明、奥寺康司、立石陽子、小島陽子、大橋健一
Organizer
第73回日本癌学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2014-09-25 – 2014-09-27
Related Report
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