Regulation of early B cell development by the CCR4-NOT deadenylase complex
| Project/Area Number |
25860358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
INOUE Takeshi 大阪大学, 免疫学フロンティア研究センター, 特任助教 (80466838)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | B細胞分化 / CCR4-NOT複合体 / mRNA分解 / p53 / mRNA代謝 / deadenylase / CCR4-NOT / CNOT3 |
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| Outline of Final Research Achievements |
Post-transcriptional gene regulation is a key regulatory mechanism underlying mammalian cell differentiation and development. To elucidate physiological functions of the CCR4-NOT deadenylase complex, we analyzed the function of CNOT3 subunit of this complex using B cell development as a model system. We generated B-cell specific Cnot3-deficient mice and found that CNOT3 has an essential role for early B cell development. Furthermore, we identified a physiological target mRNA of this complex in early B cells.
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Report
(3 results)
Research Products
(7 results)
