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Pharmacogenetics for IBD drug

Research Project

Project/Area Number 25860539
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Urabe Yuji  国立研究開発法人理化学研究所, 統合生命医科学研究センター, 客員研究員 (10648033)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsSNP / IBD / Pharmacogenetics / drug / 炎症性腸疾患 / 一塩基多型 / 薬理遺伝学
Outline of Final Research Achievements

Recently, the development of various new drugs for inflammatory bowel disease (IBD) has improved the rate of remission maintenance. Nevertheless, the methods for remission maintenance and/or permanent treatment for IBD are complicated according to the various types of IBD treatments available. The aim of this study was to clarify the genetic factors contributing to the treatment effect for IBD. Genomic DNA was extracted from approximately 600 IBD patients, and the single nucleotide polymorphisms (SNPs) of genes associated with the treatment effect of IBD drugs were determined using a multiplex polymerase chain reaction-based invader assay. We explored susceptibility genes for the effects of IBD drugs; however, did not discover any significant association of the SNPs tested with the effect of IBD drugs.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All Other

All Remarks (2 results)

  • [Remarks] 広島大学大学院医歯薬保健学研究員消化器・代謝内科

    • URL

      http://home.hiroshima-u.ac.jp/naika1/research_profile/performance_list/post.php

    • Related Report
      2014 Research-status Report
  • [Remarks] 広島大学消化管研究室

    • URL

      http://home.hiroshima-u.ac.jp/gitract/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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