Massively-Parallel Sequencing reveals molecular mechanism of gastric carcinogenesis after helicobactor pylori eradication

Research Project

Project/Area Number	25860548
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	Sapporo Medical University
Principal Investigator	SUZUKI Ryo 札幌医科大学, 医学部, 研究員 (60646587)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	胃がん / メチル化 / バイオマーカー / ピロリ菌
Outline of Final Research Achievements	We performed prospective cohort study designed to assess the utility of DNA methylation as a predictive marker of metachronous GC risk.We found that methylation of miR-34b/c, SFRP2 and DKK2 in the gastric body mucosa was strongly associated with a risk for metachronous GC, and miR-34b/c showed the greatest potential to serve as a predictive marker.Furthermore, we found that miR-34b/c methylation was also associated with metachronous GC risk in patients who underwent successful H. pylori eradication after treatment of their GC.

Report

(3 results)