The mechanisms of chemoresistance induced by amphiregulin nuclear translocation
Project/Area Number |
25860552
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
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Research Collaborator |
Yun Chris Emory University School of Medicine, Division of Digestive Diseases
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 消化器癌 / シグナル伝達 / トランスジェニックマウス / 大腸癌 / 膵臓癌 / 癌増殖能 / 発癌 / バイオマーカー検索 / 国際情報交換 / アメリカ / バイオマーカー探索 |
Outline of Final Research Achievements |
We identified two promising factors, Lysophosphatidic acid receptor 2 (LPA) and Na+/H+ exchange regulatory factor 2 (NHERF2) which have some funcions to regulate AR and induce chemoresistance. However, the analysis with clinical samples showed that AR expression did not contribute poor prognosis and the additional laboratory investigation was not able to detect AR nuclear translocation in pancreatic cancer cell lines, which required the revision of our initial study design. We focused on LPA2 and NHERF2 as the oncogenic and chemoresistant factor in colon cancer, instead of pancreatic cancer. We kept experiments and got data which showed LPA2 and NHERF2 had specific functions in terms of carciogenesis and chemoresistance. In addition, we performed SNPs and IHC analysis in pancreatic cancer patients and found p53 and MDM2 as specific biomarkers.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] Maltotriose conjugated to a chlorin derivative enhances the antitumor effects of photodynamic therapy in peritoneal dissemination of pancreatic cancer.2017
Author(s)
Kato A, Kataoka H, Yano S, Hayashi K, Hayashi N, Tanaka M, Naitoh I, Ban T, Miyabe K, Kondo H, Yoshida M, Fujita Y, Hori Y, Natsume M, Murakami T, Narumi A, Nomoto A, Naiki-Ito A, Takahashi S, Joh T
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Journal Title
Mol Cnacer Ther
Volume: 印刷中
Issue: 6
Pages: 1124-1132
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Novel characteristics of traction force in biliary self-expandable metallic stents.2016
Author(s)
Hori Y, Hayashi K, Yoshida M, Naitoh I, Ban T, Miyabe K, Kondo H, Nishi Y, Umemura S, Fujita Y, Natsume M, Kato A, Ohara H, Joh T.
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Journal Title
Dig Endosc
Volume: 印刷中
Issue: 3
Pages: 347-352
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New concept of traction force applied to biliary self-expandable metallic stents.2016
Author(s)
Hori Y, Hayashi K, Yoshida M, Naitoh I, Nakazawa T, Miyabe K, Shimizu S, Kondo H, Nishi Y, Umemura S, Kato A, Ohara H, Joh T.
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Journal Title
Endoscopy
Volume: 48
Issue: 05
Pages: 472-476
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical features of acute obstructive suppurative pancreatic ductitis: a retrospective review of 20 cases.2016
Author(s)
Kondo H, Naitoh I, Okumura F, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
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Journal Title
J Gastroenterol Hepatol
Volume: 印刷中
Related Report
Peer Reviewed / Open Access
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[Journal Article] Predictive factors for positive diagnosis of malignant biliary strictures by transpapillary brush cytology and forceps biopsy2016
Author(s)
Naitoh I, Nakazawa T, Kato A, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kuno T, Takahashi S, Ohara H, Joh T
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Journal Title
J Dig Dis
Volume: 17
Issue: 1
Pages: 44-51
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Endoscopic retrograde cholangiopancreatography-related adverse events in patients with type 1 autoimmune pancreatitis.2016
Author(s)
Naitoh I, Nakazawa T, Okumura F, Takada H, Hirano A, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Yamashita H, Sano H, Ohara H, Joh T.
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Journal Title
Pancreatology.
Volume: 16
Issue: 1
Pages: 78-82
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/22015
Author(s)
Kato A, Naiki-Ito A, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Mori T, Tsutsumi M, Kuno T, Suzuki S, Kato H, Ohara H, Joh T, Takahashi S
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Journal Title
Oncotarget
Volume: 6
Issue: 40
Pages: 42963-42975
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Correlation between long-term outcome and steroid therapy in type 1 autoimmune pancreatitis: relapse, malignancy and side effect of steroid.2015
Author(s)
Shimizu S, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Okumura F, Sano H, Hirata Y, Takada H, Ohara H, Joh T.
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Journal Title
Scand J Gastroenterol
Volume: 50
Issue: 11
Pages: 1411-1418
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal adenocarcinoma.2015
Author(s)
Hori Y, Miyabe K, Yoshida M, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Umemura S, Kato A, Ohara H, Inagaki H, Joh T.
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Journal Title
PLoS One
Volume: 10
Issue: 3
Pages: e0118829-e0118829
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Stent underexpansion on the procedure day is a predictive factor for poor oral intake after metallic stenting for gastric outlet obstruction.2015
Author(s)
Hori Y, Naitoh I, Ban T, Narita K, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Yamada T, Ando T, Joh T.
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Journal Title
J Gastroenterol Hepatol
Volume: -
Issue: 8
Pages: 1246-1251
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 8-mm versus 10-mm diameter self-expandable metallic stent in bilateral endoscopic stent-in-stent deployment for malignant hilar biliary obstruction.2015
Author(s)
Naitoh I, Nakazawa T, Ban T, Okumura F, Hirano A, Takada H, Togawa S, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Yamashita H, Umemura S, Hori Y, Kato A, Sano H, Joh T.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 22
Issue: 5
Pages: 396-401
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of intraductal ultrasonography findings between primary sclerosing cholangitis and IgG4-related sclerosing cholangitis.2015
Author(s)
Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Okumura F, Sano H, Ohara H, Joh T.
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Journal Title
J Gastroenterol Hepatol
Volume: 30
Issue: 6
Pages: 1104-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction.2015
Author(s)
Miyabe K, Hayashi K, Nakazawa T, Sano H, Yamada T, Takada H, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
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Journal Title
Dig Endosc
Volume: -
Issue: 5
Pages: 572-81
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Locus/Chromosome aberrations in intraductal papillary mucinous neoplasms analyzed by fluorescence in situ hybridization.2015
Author(s)
Miyabe K, Hori Y, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Kato A, Ohara H, Joh T, Inagaki H.
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Journal Title
Am J Surg Pathol.
Volume: 39
Issue: 4
Pages: 512-20
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison study of immunohistochemical staining for the diagnosis of type 1 autoimmune pancreatitis.2014
Author(s)
Miyabe K, Notohara K, Nakazawa T, Hayashi K, Naitoh I, Shimizu S, Kondo H, Yoshida M, Yamashita H, Umemura S, Hori Y, Kato A, Takahashi S, Ohara H, Joh T.
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Journal Title
J Gastroenterol.
Volume: 50
Issue: 4
Pages: 455-66
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A comparison of the diagnostic efficacy in type 1 autoimmune pancreatitis based on biopsy specimens from various organs2014
Author(s)
Yamashita H, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo M, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Takahashi S, Joh T
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Journal Title
Pancreatology
Volume: Vol14
Issue: 3
Pages: 186-192
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy of pancreatic stenting prior to extracorporeal shock wave lithotripsy for pancreatic stones.2014
Author(s)
Kondo H, Naitoh I, Ohara H, Nakazawa T, Hayashi K, Okumura F, Miyabe K, Shimizu S, Nishi Y, Yoshida M, Yamashita H, Umemura S, Hori Y, Kato A, Joh T.
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Journal Title
Dig Liver Dis.
Volume: 46
Issue: 7
Pages: 639-44
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] NHERF2 regulates colon cancer progress via stat32016
Author(s)
M. Yoshida, Hayashi, I. Naitoh, T. Ban, H. Kondo, Y. Nishi, S. Umemura, Y. Fujita, M. Natsume, A. Kato, H. Ohara, T. Joh
Organizer
UEG Week Vienna 2016
Place of Presentation
ウィーン(オーストリア)
Year and Date
2016-10-17
Related Report
Int'l Joint Research
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[Presentation] Transgenic expression of human lysophosphatidic acid receptor (LPA2) in mouse intestinal epithelial cells induces intestinal dysplasia2016
Author(s)
M. Yoshida, Hayashi, I. Naitoh, T. Ban, H. Kondo, Y. Nishi, S. Umemura, Y. Fujita, M. Natsume, A. Kato, H. Ohara, T. Joh
Organizer
UEG Week Vienna 2016
Place of Presentation
ウィーン(オーストリア)
Year and Date
2016-10-17
Related Report
Int'l Joint Research
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