| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
This study aims to experimentally verify the fundamental therapy for arrhythmia induced by oxidative stress.
Experiments using heterozygous heart/muscle-specific manganese superoxide-deficient mice revealed that myocardial hyper-oxidative stress reduces the expression of potassium channel-related factors, including fetal protein, and causes electrical remodeling. The research results were reported as a paper presentation. In addition, we started a therapeutic intervention study with semaphorin 3A (Sema3A), a fetal protein regulator, using the isoproterenol (ISP)-loaded myocardial mouse model. We have confirmed myocardial remodeling due to ISP and we plan to verify the therapeutic effects of Sema3A.
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