Ectopic fat accumulation and distant organ-specific insulin resistance
Project/Area Number |
25860744
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 臓器特異的インスリン抵抗性 / ヘパトカイン / セレノプロテインP / 肝インスリン抵抗性 / 骨格筋インスリン感受性 / インスリン抵抗性 / 細胞内脂肪蓄積 / 高インスリン正常血糖クランプ検査 |
Outline of Final Research Achievements |
Organ-specific IR in the liver (hepatic glucose production (HGP) × fasting plasma insulin (FPI) and suppression of HGP by insulin [%HGP]), skeletal muscle (insulin-stimulated glucose disposal [Rd]), and adipose tissue (suppression of FFA by insulin [%FFA]) was measured in 69 patients with NAFLD using a euglycemic hyperinsulinemic clamp. Liver fat, intramyocellular lipid (IMCL), and body composition were measured by liver biopsy, proton magnetic resonance spectroscopy, and bioelectrical impedance analysis, respectively. Unexpectedly, fat accumulation in the skeletal muscle and adipose tissue was not associated with organ-specific IR. Instead, liver fat was associated not only with hepatic IR but also with skeletal muscle IR, suggesting a central role of fatty liver in systemic IR and that a network exists between liver and skeletal muscle.
|
Report
(4 results)
Research Products
(32 results)
-
-
-
[Journal Article] Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy.2015
Author(s)
Takazakura A, Sakurai M, Bando Y, Misu H, Takeshita Y, Kita Y, Shimizu A, Hayakawa T, Kato K, Kaneko S, Takamura T.
-
Journal Title
J Diabetes Investig
Volume: 6
Pages: 346-353
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: A randomized, parallel-group study.2015
Author(s)
Takeshita Y, Takamura T, Kita Y, Otoda T, Kato K, Wakakuri H, Yamada M, Misu H, Matsushima Y,Kaneko S; Establishment of Rationale for Antiaging Diabetic Medicine (ERA-DM) Study Chapter 2 Group
-
Journal Title
J Diabetes Investig
Volume: 6
Pages: 192-200
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis.2015
Author(s)
Yamada K, Mizukoshi E, Sunagozaka H, Arai K, Yamashita T, Takeshita Y, Misu H, Takamura T, Kitamura S, Zen Y, Nakanuma Y, Honda M, Kaneko S.
-
Journal Title
Liver Int.
Volume: 35
Pages: 582-590
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum.2014
Author(s)
Tanaka M, Saito Y, Misu H, Kato S, Kita Y, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Takamura T, Kaneko S, Takahashi K, Matsuyama N
-
Journal Title
J Clin Lab Anal.
Volume: Dec
Pages: 26-26
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
Author(s)
Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T.
-
Journal Title
Diabetologia.
Volume: 57
Pages: 1968-1976
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance.2014
Author(s)
Lan F, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, Takata N, Hayashi H, Matsuzawa-Nagata N, Takeshita Y, Noda H, Matsumoto Y, Ota T, Nagano T, Nakagen M, Miyamoto K, Takatsuki K, Seo T, Iwayama K, Tokuyama K, Matsugo S, Tang H, Saito Y, Yamagoe S, Kaneko S,Takamura T.
-
Journal Title
Diabetes.
Volume: 63
Pages: 1649-1664
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic Fatty liver disease.2014
Author(s)
Kato K, Takamura T, Takeshita Y, Ryu Y, Misu H, Ota T, Tokuyama K, Nagasaka S, Matsuhisa M, Matsui O, Kaneko S.
-
Journal Title
NAID
Related Report
Peer Reviewed
-
[Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.2014
Author(s)
Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S.
-
Journal Title
Diabetologia
Volume: 57
Pages: 878-890
Related Report
Peer Reviewed
-
[Journal Article] Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.2013
Author(s)
Otoda T, Takamura T, Misu H, Ota T, Murata S, Hayashi H, Takayama H, Kikuchi A, Kanamori T, Shima KR, Lan F, Takeda T, Kurita S, Ishikura K, Kita Y, Iwayama K, Kato K, Uno M, Takeshita Y, Yamamoto M, Tokuyama K, Iseki S, Tanaka K, Kaneko S.
-
Journal Title
Diabetes.
Volume: 62
Pages: 811-824
Related Report
Peer Reviewed
-
[Journal Article] Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T₂ correction: phantom and clinical study with histologic assessment.2013
Author(s)
Hayashi N, Miyati T, Minami T, Takeshita Y, Ryu Y, Matsuda T, Ohno N, Hamaguchi T, Kato K, Takamura T, Matsui O.
-
Journal Title
Radiol Phys Technol.
Volume: 6
Pages: 219-225
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-