Role of 15-lipoxygenase in the regulation of pulmonary eosinophilic inflammation
| Project/Area Number |
25860816
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | The Institute of Physical and Chemical Research (2014)
The University of Tokyo (2013) |
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Principal Investigator |
MIYATA Jun 独立行政法人理化学研究所, 統合生命医科学研究センター, 基礎科学特別研究員 (80464866)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 15-リポキシゲナーゼ / 12/15－リポキシゲナーゼ / プロテクチンD1 / DHA / 自然免疫 / 好酸球 / 12/15-リポキシゲナーゼ |
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| Outline of Final Research Achievements |
We identified that 12/15-lipoxygenase(12/15-LOX) has protective roles in the regulation of innate type of airway eosinophilic inflammation by using 12/15-LOX gene knockout mice. The numbers of main IL-5-producing lymphocytes were increased in 12/15-LOX knockout mice. Lipidomic analysis of lung revealed large amounts of 12/15-lipoxygenase metabolites during the initiation phase of pulmonary inflammation, which are impaired in 12/15-lipoxygenase knockout mice. We also showed the direct suppressive effects of these 12/15-LOX-derived metabolites on the functions of IL-5-producing lymphocytes.
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Report
(3 results)
Research Products
(2 results)
