Usefulness of a Novel and Rapid Assay System for Fecal Calprotectin in Pediatric Patients with Inflammatory Bowel Diseases.

• Project/Area Number: 25860889
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Osaka Medical College
• Principal Investigator: AOMATSU Tomoki 大阪医科大学, 医学部, 助教 (10465619)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 炎症性腸疾患 / 小児 / バイオマーカー / カルプロテクチン / 疾患活動性

Outline of Final Research Achievements

Novel assay system for fecal calprotectin (FC), colloidal gold aggragation assay (CGA), had excellent performance for assessing mucosal inflammation of pediatric inflammatory bowel diseases, and can be replaced for conventional ELISA. FC measured by CGA was also useful for assessing mucosal healing and identifying subclinical inflammation of the colon.

Research Products

• [Journal Article] Usefulness of a Novel and Rapid Assay System for Fecal Calprotectin in Pediatric Patients with Inflammatory Bowel Diseases (2014)
  • Author(s): Keisuke Inoue, Tomoki Aomatsu, Atsushi Yoden, Takeru Okuhira, Emiri Kaji, Hiroshi Tamai
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: Epub Issue: 7 Pages: 1406-1212
  • DOI: 10.1111/jgh.12578
  • Peer Reviewed
• [Presentation] 小児炎症性腸疾患における新規便中カルプロテクチン測定法の有用性 (2014)
  • Author(s): 青松友槻
  • Organizer: JDDW2014
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] 小児炎症性腸疾患おける、新規便中カルプロテクチン測定法の有用性 (2014)
  • Author(s): 井上敬介
  • Organizer: 第41回日本小児栄養消化器肝臓学会
  • Place of Presentation: 東京ステーションコンファレンス（東京都千代田区）
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Usefulness of a Novel and Rapid Assay System for Fecal Calprotectin in Pediatric Patients with Inflammatory Bowel Diseases (2014)
  • Author(s): 青松友槻
  • Organizer: PIBD2014
  • Place of Presentation: De Doelen Congress Centre (ロッテルダム、オランダ)
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 小児炎症性腸疾患における新規便中カルプロテクチン測定法の有用性 (2014)
  • Author(s): 井上敬介、青松友槻、余田篤、玉井浩
  • Organizer: 日本小児栄養消化器肝臓学会
  • Place of Presentation: 東京