Regulation of cytoplasmic HDACs relating HSP90 protein

• Project/Area Number: 25860965
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Iwate Medical University
• Principal Investigator: ISHIKAWA Yuichi 岩手医科大学, 医学部, 助教 (20633142)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 皮膚腫瘍学 / HSP90 / CYLD / ERBB2 / HSF1 / NACC1

Outline of Final Research Achievements

Heat shock protein 90 (HSP90) is a unique shaperon protein which ERBB2, AKT, RAF, BCR-ABL and mutant p53 proteins are client proteins controlling their conformational change. The present study could not demonstrated the direct interaction between nucleus accumbens-associated protein 1 (NACC1) and deubiquitinase, cylindromatosis (CYLD) resulting in downregulation HSP90 functions.