Possible molecular mechanisms of normal cells and invasive breast cancer cells after radiation treatment
| Project/Area Number |
25861050
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
NAM JINMIN 北海道大学, 国際連携研究教育局, 助教 (60414132)
|
|---|
| Research Collaborator |
ONODERA YASUHITO 北海道大学, 大学院医学研究科, 講師 (90435561)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 放射線 / 乳癌 / ３次元培養 / 3次元培養 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated molecular mechanisms to improve the radiation therapy by targeting specific molecules which are involved in not only preservation of the functions in normal cell structure but also suppressing tumor growth, recurrence and metastasis. To find candidate genes, we performed microarray analysis in a mammary epithelial cell line which has basal polarity, or invasive breast cancer cell lines in three-dimensional laminin rich extracellular matrix (3D lrECM). We found that β1-integrin and its downstream molecules are involved in the disruption of basal polarity structure and invasive transition on non-malignant mammary epithelial cells in 3D lrECM. In addition, we also found that up-regulated integrin expression on the cell surface may have important roles in the invasive activity after radiation treatment in breast cancer cells.
|
Report
(4 results)
Research Products
(9 results)
-
-
-
[Journal Article] β1-integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer.2013
Author(s)
Nam JM, Ahmed KM, Costes S, Zhang H, Onodera Y, Olshen AB, Hatanaka KC, Kinoshita R, Ishikawa M, Sabe H, Shirato H, Park CC
-
Journal Title
Breast Cancer Res
Volume: 15
Related Report
Peer Reviewed
-
[Journal Article] Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.2013
Author(s)
Kinoshita R, Nam JM, Ito YM, Hatanaka KC, Hashimoto A, Handa H, Otsuka Y, Hashimoto S, Onodera Y, Hosoda M, Onodera S, Shimizu S, Tanaka S, Shirato H, Tanino M, Sabe H.
-
Journal Title
PLoS One.
Volume: 8
Issue: 10
Pages: e76791-e76791
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
