| Project/Area Number |
25861154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
OGAWA Eri 京都大学, 医学(系)研究科(研究院), 助教 (30440506)
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| Research Collaborator |
YOSHIZAWA Atsushi 京都大学, 医学研究科, 特定助教 (60457984)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 小児肝移植 / 移植免疫 / 抗体反応 / 肝移植 / 抗ドナー抗体 / 小児外科 / 抗体関連拒絶 / HLA |
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| Outline of Final Research Achievements |
We previously reported the correlation between the existence of donor specific anti- human leukocyte antigen antibodies (DSA) and progressive fibrosis in late liver graft after pediatric living donor liver transplantation (LDLT) (>5years). The frequency of DSA was 48%. In this study, we analyzed the frequency of de-novo DSA occurrence and their impact on clinical outcome in early liver graft (<3 years).
38.6％ of the recipients showed de-novo DSA at the time of liver biopsy. DSA were mainly against HLA Class II. The pathological findings of de-novo DSA-positive recipients are as follows; 45.5% of DSA+ recipients showed Acute and chornic rejection. 25% of DSA- patients showed ACR. (p=0.088)
The following factors have emerged as risk factors of positive DSA; high donor age, past history of ACR, reduction of immunosuppression due to infection.
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