Development of the new therapy using the ray radiation on inflammatory bowel disease

Research Project

Project/Area Number	25861205
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Digestive surgery
Research Institution	Oita University
Principal Investigator	Hiratsuka Takahiro 大分大学, 医学部, 助教 (20600886)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	LED光線 / 光線療法 / DSS誘導大腸炎 / disease activity index
Outline of Final Research Achievements	The body surface radiation to the 2.5% dextran sulfate sodium - induced colitis mouse of LED rays significantly reduced disease activity index score of the colitis and significantly decreased shortening of the length of large intestine. Whereas the significant change of the lymphocytes marker (CD4, CD8, B220, Foxp3) in murine spleen irradiated with LED rays was not found. The LED rays wavelength (patent pending) of a certain wavelength has a colitis improvement effect. A search of the further mechanism, optimal condition may lead to new therapy for inflammatory bowel disease.

Report

(4 results)