Clarifying the pathophysiology of early brain injury after subarachnoid hemorrhage focusing on matricellular proteins.
| Project/Area Number |
25861272
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
SHIBA Masato 三重大学, 医学部附属病院, 診療等従事者 (30595682)
|
|---|
| Research Collaborator |
SUZUKI Hidenori
FUJIMOTO Masashi
KAWAKITA Fumihiro
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | くも膜下出血 / 早期脳損傷 / マトリセル蛋白 / テネイシンC / MAPキナーゼ / アポトーシス / 脳損傷 |
|---|
| Outline of Final Research Achievements |
We investigated the effect of tenascin-C(TNC), a matricellular protein, on pathophysiology of early brain injury after experimental subarachnoid hemorrhage(SAH) by using rats and mice endovascular perforation models. Firstly, we showed that SAH caused neuronal apoptosis in the brain with TNC upregulation. Next, we showed that intracisternally injected recombinant TNC reversed the anti-apoptotic effects in brain by imatinib. Lastly, using various inhibitors, we showed that early brain injury was improved with inhibition of TNC upregulation by supression of MAP kinase-dependent MMP-9 induction.
|
Report
(4 results)
Research Products
(16 results)
-
-
-
-
-
-
-
-
-
-
-
[Presentation] The role of matricellular proteins in brain edema after experimental subarachnoid hemorrhage2014
Author(s)
Hidenori Suzuki, Masashi Fujimoto, Masato Shiba, Fumihiro Kawakita, Liu Lei, Naoki Ichikawa, Kenji Kanamaru, Kyoko Imanaka-Yoshida, Toshimichi Yoshida
Organizer
The 16th International Conference on Brain Edema and Cellular Injury
Place of Presentation
Huntington Beach, CA, USA (Hyatt Regency Huntington Beach Resort and Spa)
Year and Date
2014-09-27 – 2014-09-30
Related Report
-
-
-
-
-
