| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
The aim of this study was to establish pharmacological treatments for prevention of rupture of intracranial aneurysms. To test pharmacological therapy, we established a rat model of intracranial aneurysms in which spontaneous aneurysm rupture occurred. Female rats were subjected to estrogen deficiency, hemodynamic stress, and renal hypertension. In this model, we demonstrated that endothelial dysfunction, oxidative stress, inflammation, and high salt intake were associated with the formation of intracranial aneurysms. Various types of drugs prevent the formation of intracranial aneurysms. Furthermore, to examine the mechanisms of aneurysmal rupture, we modified this model. In modified model, rats had a higher incidence of aneurysmal rupture. In the future study, we will examine the mechanisms of aneurysmal rupture and test the pharmacological therapy for prevention of aneurysmal rupture.
|
