Development of hypoxia-imaging in brain tumors using 7 Tesla MRI

• Project/Area Number: 25861287
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: UWANO Ikuko 岩手医科大学, 医学部, 助教 (20468317)
• Research Collaborator: KUDO Kohsuke ; OGASAWARA Kuniaki ; BEPPU Takaaki ; SASAKI Makoto
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 7テスラMRI / 定量的磁化率マップ / 酸素摂取率 / 位相画像 / 脳腫瘍 / 低酸素イメージング

Outline of Final Research Achievements

In this study, we evaluated the performance and efficacy for intensity inhomogeneity correction of various sequences of the human brain in 7 Tesla MRI using the extended version of the unified segmentation algorithm, and we found all of these intensity inhomogeneities were successfully corrected and the contrast between different tissue types was maintained after inhomogeneity correction. In addition, we investigated whether oxygen extraction fraction (OEF) maps that were generated with a quantitative susceptibility mapping (QSM) technique at 7 Tesla would demonstrate OEF changes in patients with major cerebrovascular steno-occlusive disease compared with OEF maps that were generated with PET, and as a result the OEF ratios on QSM-OEF maps at 7 Tesla correlated well with those on PET-OEF maps in patients with steno-occlusive cerebrovascular diseases.

Research Products

• [Journal Article] Assessment of Sensations Experienced by Subjects during MR Imaging Examination at 7T (2015)
  • Author(s): Uwano I, Metoki T, Sendai F, Yoshida R, Kudo K, Yamashita F, Higuchi S, Ito K, Harada T, Goodwin J, Ogawa A, Sasaki M
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 1 Pages: 35-41
  • DOI: 10.2463/mrms.2014-0004
  • NAID: 130004700395
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Susceptibility-Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI (2014)
  • Author(s): Jonathan A. Goodwin, Kohsuke Kudo, Yutaka Shinohe, Satomi Higuchi, Ikuko Uwano, Fumio Yamashita and Makoto Sasaki
  • Journal Title: Journal of Neuroimaging Volume: 00 Issue: 4 Pages: 1-7
  • DOI: 10.1111/jon.12192
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bayesian Analysis of Perfusion-weighted Imaging to Predict Infarct Volume: Comparison with Singular Value Decomposition (2014)
  • Author(s): Kudo K, Boutelier T, Pautot F, Honjo K, Hu JQ, Wang HB, Shintaku K, Uwano I, Sasaki M
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 13 Issue: 1 Pages: 45-50
  • DOI: 10.2463/mrms.2013-0085
  • NAID: 130003392992
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Intensity inhomogeneity correction for magnetic resonance imaging of human brain at 7T (2014)
  • Author(s): Uwano I, Kudo K, Yamashita F, Goodwin J, Higuchi S, Ito K, Harada T, Ogawa A, Sasaki M
  • Journal Title: Med Phys Volume: 41(2) Issue: 2 Pages: 22302-22302
  • DOI: 10.1118/1.4860954
  • Peer Reviewed
• [Presentation] Measurement of Oxygen Extraction Fraction in Patients with Steno-occlusive Cerebrovascular Diseases using Quantitative Susceptibility Mapping at 7T (2015)
  • Author(s): Uwano I, Sasaki M, Kudo K, Sato R, Sato Y, Ogasawara Y, Saura H, Ogasawara K, Harada T, Ito K, Yamashita F, Goodwin J, Higuchi S
  • Organizer: ISMRM 23rd Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-30 – 2015-06-05
• [Presentation] 7T-MRIの定量的磁化率マップによるOEF計測：主幹動脈病変患者のPET画像との比較 (2015)
  • Author(s): 上野 育子、佐々木 真理、工藤 與亮、佐藤 良太、小笠原 邦昭、原田 太以佑、伊藤 賢司、山下 典生、樋口 さとみ
  • Organizer: 第38回日本脳神経CI学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] 7 Tesla定量的磁化率マップ(QSM)を用いたOEF画像：主幹動脈病変患者への応用とPETとの比較 (2014)
  • Author(s): 上野 育子、工藤 與亮、佐藤 良太、佐藤 由衣子、小笠原 靖、佐浦 宏明、小笠原 邦昭、ジョナサン グッドウィン、山下 典生、樋口さとみ、伊藤 賢司、原田 太以佑、佐々木 真理
  • Organizer: 第21回東北脳循環カンファランス
  • Place of Presentation: 仙台
  • Year and Date: 2014-10-18
• [Presentation] Subjective Assessment of Sensations Experienced by 7 Tesla Magnetic Resonance Imaging (2014)
  • Author(s): Uwano I, Metoki T, Sendai F, Yoshida R, Kudo K, Yamashita F, Higuchi S, Ito K, Harada T, Goodwin J, Sasaki M
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Intensity Inhomogeneity Correction in Human Brain Imaging at 7 Tesla using SPM8 (2013)
  • Author(s): Uwano I, Kudo K, Yamashita F, Metoki T, Goodwin J, Higuchi S, Ito K, Yokosawa S, Sasaki M
  • Organizer: ISMRM 21st Annual Meeting
  • Place of Presentation: Salt Lake City, USA