The functional study about mechanisms of the sacral acupuncture stimulus to overactive bladder, bladder inflammation model rats.

• Project/Area Number: 25861456
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: HINO KOKORO 明治国際医療大学, 鍼灸学部, 講師 (30555652)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 頻尿 / ラット / カンナビノイド受容体 / 仙骨部 / 鍼刺激 / 鍼灸 / シストメトリー / 膀胱 / 膀胱炎 / モデルラット / 仙骨部鍼刺激

Outline of Final Research Achievements

The aim of this study is to elucidate the mechanisms of sacral acupuncture stimulation for overactive bladder model rats. The intercontraction interval (ICI) was prolonged after sacral acupuncture stimulation in acetic acid-induced bladder irritation (AA) rats and hydrochloric-induced cystitis rats but cychrophosphamide-induced cystitis rats. The effect of sacral acupuncture stimulation might be different from the cause of bladder conditions. The stimulation of moxibution to lower abdomen was more prolonged ICI than sacral stimulation of moxibution in AA rats. The difference of stimulation modalities would affect the effectiveness of stimulation of sacral lesion. Cannabinoid 1 (CB1) receptor inhibitor suppressed the prolonged ICI by sacral acupuncture stimulation in AA rats. It was considered that CB1 receptor could be a part of mechanisms of sacral acupuncture stimulation for overactive bladder.

Research Products

• [Journal Article] Contributions of ADP and ATP to the increase in skeletal muscle blood flow after manual acupuncture stimulation in rats. (2016)
  • Author(s): Nagaoka S, Shinbara H, Okubo M, Kawakita T, Hino K, Sumiya E.
  • Journal Title: Acupunct Med. Volume: 0 Issue: 3 Pages: 1-6
  • DOI: 10.1136/acupmed-2015-010959
  • Peer Reviewed
• [Journal Article] 鍼回旋刺激および輻射熱刺激による後外側腹側核の侵害受容性ニューロンの活動の抑制 鍼鎮痛における上行性痛覚抑制系の関与の可能性. (2013)
  • Author(s): 小笠原千絵，谷口博志, 新原寿志, 日野こころ, 角谷英治
  • Journal Title: 明治国際医療大学誌 Volume: 8 Pages: 23-39
  • NAID: 110009595898
  • Peer Reviewed
• [Journal Article] 灸頭鍼における艾球の中心温度と落下地点の温度. (2013)
  • Author(s): 長岡里美, 新原寿志, 日野こころ, 谷口博志, 角谷英治
  • Journal Title: 全日本鍼灸学会誌 Volume: 63 Pages: 167-175
  • NAID: 130004513518
  • Peer Reviewed
• [Presentation] 勃起機能に対する中りょう穴への鍼通電刺激の影響 ラット陰茎海綿体内圧を指標とした検討 (2014)
  • Author(s): 伊佐治 景悠, 谷口 博志, 今井 賢治, 谷口 授, 日野 こころ, 新原 寿志, 北小路 博司, 角谷 英治
  • Organizer: 全日本鍼灸学会学術大会
  • Place of Presentation: 愛媛県
  • Year and Date: 2014-05-16 – 2014-05-18
• [Presentation] マニュアル鍼刺激による局所骨格筋血流量増加の解明 鍼刺激局所のアデノシンとATP及びADPの動態 (2014)
  • Author(s): 長岡 里美, 新原 寿志, 日野 こころ, 谷口 博志, 角谷 英治
  • Organizer: 全日本鍼灸学会学術大会
  • Place of Presentation: 愛媛県
  • Year and Date: 2014-05-16 – 2014-05-18
• [Presentation] The mechanisms of Sacral Acupuncture on Acetic Acid-induced Bladder Overactivity in Conscious Rats (2013)
  • Author(s): Hino K, Udo Y, Sumiya E.
  • Organizer: GUNTM international symposium 2013
  • Place of Presentation: Kyoto
• [Presentation] Contribution of ATP to an increase in local muscle blood flow following manual acupuncture.
  • Author(s): Nagaoka S, Shinbara H, Hino K, Taniguchi H, Sumiya E.
  • Organizer: GUNTM International Symposium 2013
  • Place of Presentation: Kyoto
• [Presentation] Evidence for an ascending inhibitory pathway of acupuncture analgesia.
  • Author(s): Ogasawara C, Taniguchi H, Shinbara H, Hino K, Sumiya E
  • Organizer: GUNTM international symposium 2013
  • Place of Presentation: Kyoto
• [Presentation] The excitatory response of the neurons in periaqueductal gray matter/ dorsal raphe nucleus, ventrobasal complex and nucleus accumbens to press tack needle.
  • Author(s): Sumiya E, Ogasawara C, Hayama S, Sato S, Shinbara H, Taniguchi H, Hino K
  • Organizer: GUNTM international symposium 2013
  • Place of Presentation: Kyoto
• [Presentation] 睡眠満足度の評価に対する基礎的検討 大学生における予備的検討.
  • Author(s): 日野こころ, 有働幸紘, 新原寿志, 小笠原千絵, 佐藤想一朗, 長岡里美, 早野大孝, 角谷英治
  • Organizer: 第62回全日本鍼灸学会学術大会
  • Place of Presentation: 福岡
• [Book] 緩和ケア鍼灸マニュアル (2014)
  • Author(s): 糸井啓純、篠原昭二
  • Total Pages: 298
  • Publisher: 医歯薬出版株式会社