Clinical significance of neutrophils in the pathology of endometriosis
| Project/Area Number |
25861472
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 好中球 / 好中球除去 / 子宮内膜症 / プロバイオティクス / IL-4 / 3β-ヒドロキシステロイド脱水酵素 / Th2 / PGE2 / エストロゲン |
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| Outline of Final Research Achievements |
We purified Anti Gr-1 antibody, and confirmed that intra peritoneal injection of this antibody to mice effectively depleted neutrophils from peripheral blood, without affecting other white blood cells. In endometriosis model mice, much less neutrophils were present at endometriotic lesions in depleted mice using NIMP14, a marker of neutrophils. The depletion of neutrophils suppressed the number and total weight of endometriosis at the initial phase, but not at the later phase. No significant difference were observed as to the concentration of inflammatory cytokines.
Probiotics suppressed endometriotic lesion when administrated after the infusion of endometrium. Among white blood cell in the washed peritoneal fluid, only neutrophils were significantly decreased, which imply the mechanism of the suppression.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells.2014
Author(s)
Urata Y, Koga K, Hirota Y, Akiyama I, Izumi G, Takamura M, Nagai M, Harada M, Hirata T, Yoshino O, Kawana K, Fujii T, Osuga Y.
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Journal Title
Am J Reprod Immunol.
Volume: 72
Issue: 5
Pages: 496-503
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis.2014
Author(s)
Miyashita M, Koga K, Takamura M, Izumi G, Nagai M, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.
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Journal Title
Gynecol Endocrinol.
Volume: 30
Issue: 9
Pages: 644-648
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Role of Bone Morphogenetic Protein 6 in Accumulation and Regulation of Neutrophils in the Human Ovary.2014
Author(s)
Akiyama I, Yoshino O, Osuga Y, Shi J, Takamura M, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S
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Journal Title
Reproductive Science
Volume: epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinases-1 (MMP-1) from human decidual cells, and the production was reduced by progesterone.2013
Author(s)
.Zhao Y, Koga K, Osuga Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Inoue S, Fujii T, Kozuma S.
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Journal Title
American journal of reproductive immunology
Volume: 69 (5)
Pages: 454462-454462
Related Report
Peer Reviewed
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[Journal Article] Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells.2013
Author(s)
Urata Y, Osuga Y, Akiyama I, Nagai M, Izumi G, Takamura M, Hasegawa A, Harada M, Hirata T, Hirota Y, Yoshino O, Koga K, Kozuma S.
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Journal Title
Jounal of Clinical Endocrinology & Metabolism
Volume: 98(4)
Pages: 15831590-15831590
Related Report
Peer Reviewed
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