| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
To release immunosuppressive microenvironment of ovarian cancer, we focused on statins. In ovarian clear cell carcinoma cell lines, cancer signal NF-kB and STAT were both suppressed by statin drugs (Simvastatin and Pitavastatin), and the production of immunosuppressive cytokine LI-6 was inhibited. Statins did not affect cell proliferation. In vivo experiment using ovarian cancer transplanted mice, the mice administered with statins is promoted CD8-positive cell infiltration into the tumor, this supported the hypothesis that statins released immunosuppression. FACS analysis of the immune cells infiltrating into transplanted tumor revealed there was no change in the infiltration number of dendritic cells nor macrophages by administration of statins. For these reasons, statins, to improve the immune suppressing environment in cancer, it was suggested to enhance anti-tumor T cell responses.
|
