Relationship of sudden sensorineural hearing loss and oxidative stress.

Research Project

Project/Area Number	25861543
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Otorhinolaryngology
Research Institution	Shinshu University
Principal Investigator	KITOH Ryosuke 信州大学, 学術研究院医学系, 助教 (80419358)
Research Collaborator	NISHIO Shin-ya 信州大学, 学術研究院医学系, 助教 (70467166) USAMI Shin-ichi 信州大学, 学術研究院医学系, 教授 (10184996)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	突発性難聴 / 酸化ストレス / 遺伝子 / 耳科学 / 遺伝子多型 / SNPs
Outline of Final Research Achievements	To assess the gene association with sudden sensorineural hearing loss (SSNHL), we analyzed the 192 DNA samples from SSNHL patients registered in the intractable inner ear disease gene bank and performed genotyping of the candidate genes, 39 SNPs from 31 genes. As a result SOD1 rs4998557 could be associated with susceptibility to SSNHL in the Japanese population.

Report

(4 results)