Relationship of sudden sensorineural hearing loss and oxidative stress.
| Project/Area Number |
25861543
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
KITOH Ryosuke 信州大学, 学術研究院医学系, 助教 (80419358)
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| Research Collaborator |
NISHIO Shin-ya 信州大学, 学術研究院医学系, 助教 (70467166)
USAMI Shin-ichi 信州大学, 学術研究院医学系, 教授 (10184996)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 突発性難聴 / 酸化ストレス / 遺伝子 / 耳科学 / 遺伝子多型 / SNPs |
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| Outline of Final Research Achievements |
To assess the gene association with sudden sensorineural hearing loss (SSNHL), we analyzed the 192 DNA samples from SSNHL patients registered in the intractable inner ear disease gene bank and performed genotyping of the candidate genes, 39 SNPs from 31 genes. As a result SOD1 rs4998557 could be associated with susceptibility to SSNHL in the Japanese population.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] SOD1 gene polymorphisms in sudden sensorineural hearing loss.2016
Author(s)
Kitoh R, Nishio SY, Ogawa K, Okamoto M, Kitamura K, Gyo K, Sato H, Nakashima T, Fukushima K, Hara A, Yamasoba T, Usami S.
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Journal Title
Acta Otolaryngol.
Volume: 136
Issue: 5
Pages: 465-469
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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