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Functional analysis of Alarmin receptors in the pathogenesis of pulpitis

Research Project

Project/Area Number 25861803
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

HIRAO Kouji  徳島大学, 大学病院, 助教 (00581399)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords歯髄炎 / 象牙芽細胞 / alarmin / MINCLE
Outline of Final Research Achievements

Alarmins, endogenous immunofactors secreted to necrosis are an important factor that becoming serious of sepsis, it hypothesized to have an important role to rapid progression of pulp necrosis in pulpitis. In this study, I focused on alarmin and its receptor, analyzed for alarmin role and function in pulpitis.
As the result, Mincle which is one of the alarmin receptor is expressed in rat odontblastic cells (KN-3) and, its expression is increased by stimulation with Pathogen-associated molecular patterns. Moreover, I demonstrated that CCL4 mRNA expression is up-regulated by the stimulation with TDM which is MINCLE rigand.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Effects of extracellular DNA and DNA-binding protein on the development of a Streptococcus intermedius biofilm.2013

    • Author(s)
      Nur A, Hirota K, Yumoto H, Hirao K, Liu D, Takahashi K, Murakami K, Matsuo T, Shu R, and Miyake Y.
    • Journal Title

      Journal of applied microbiology

      Volume: 115(1) Pages: 260-270

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Functional Roles of NOD1 in Odontoblasts on Pulp Innate Immunity2014

    • Author(s)
      Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Chihiro Shinohara and Takashi Matsuo
    • Organizer
      第62回国際歯科研究学会 日本部会総会・学術大会
    • Place of Presentation
      KKRホテル大阪(大阪府・大阪市)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット象牙芽細胞様細胞(KN3)における細菌関連病原因子刺激に対する自然免疫反応の解析2014

    • Author(s)
      平尾 功治, 湯本 浩通, 中西 正, 篠原 千尋, 高橋 加奈子, 武川 大輔, 細川 由樹, 松尾 敬志
    • Organizer
      日本歯科保存学会2014年度春学術大会
    • Place of Presentation
      滋賀県立芸術劇場(滋賀県・大津市)
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pathogenic roles of Streptococcal histon-like protein in microbial infection

    • Author(s)
      Hiromichi Yumoto, Katsuhiko Hirota, Kouji Hirao, Keiji Murakami, Yoichiro Miyake, Takashi Matsuo
    • Organizer
      The 13th Joint Sceintific Meeting of JSCD-KACJ
    • Place of Presentation
      The K Hotel & Resort, Gyeongju, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 細菌関連病原因子によるラット象牙芽細胞の自然免疫反応の解析

    • Author(s)
      平尾 功治、湯本 浩通
    • Organizer
      第87回 日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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