| Project/Area Number |
25861855
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
Miyazaki Mami 九州大学, 大学病院, 研究員 (80608977)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セラミック / 生体親和性 / カルシウム修飾 / 口腔上皮 / ジルコニア / アルミナ / 軟組織親和性 / 骨接触率 / 骨伝導性 / オゾン処理 |
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| Outline of Final Research Achievements |
We explored the affinity reaction of zirconia as an implant abutment material and soft tissue.
We examined for quantitative estimation of hydroxyl, serum protein and proliferation of epithelial cells on the face of zirconia. In oral study in rats, the implants which abutment was composed of zirconia were placed. We examined the sealing of the epithelium around zirconia.
On the face of zirconia, there are some hydroxyl groups that showed affinity for zirconia. Oral epithelial cells adhered and promoted on the surface of zirconia. There formed healthy biologic width around zirconia abutment. In addition, laminin-5 which a component of hemi-desmosome, was expressed at the interface between epithelium and zirconia. In conclusion, on the surface of zirconia, this study demonstrated that it has an adsorptive property of serum protein and adhere to epithelium by bonding structure including hemi-desmosome junction, and formed the healthy biologic width.
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