| Project/Area Number |
25861861
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生体材料 / スーパーメンブレン / アパタイト / コラーゲン複合体 / ハイドロゲル / 硬組織再生 / メンブレン / 骨補填材 / インプラント |
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| Outline of Final Research Achievements |
Membranes prepared by pressing of nano-apatite/collagen composites can be called super-membrane because they exhibited excellent osteo-conduction in rat calvarial defects. These membranes were gradually bio-absorbed while osteoclasts played a major role. Osteoclasts adhered and metabolized on aggregates of nano-apatite in collagen matrix. Near the membranes, osteoblasts actively formed new bones, leading to bone remodeling. As s result, it was considered that osteo-conduction was established. Uses of growth factors and chemicals were not needed, and it was thought that prepared super-membranes could be clinically employed in near futures.
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