Development of new Treatments for osteoarthritis using water-soluble fullerene / ubiquinone

• Project/Area Number: 25861989
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyushu Dental College (2016); Fukuoka University (2013-2015)
• Principal Investigator: OHTANI TAISHI 九州歯科大学, 歯学部, 助教 (90609504)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 変形性関節症 / 水溶性フラーレン / ナノカーボン / ユビキノン / フラーレン

Outline of Final Research Achievements

When water soluble fullerene for osteoarthritis. Water soluble fullerene for osteoarthritis. Occurrence in the culture medium, there was a tendency to suppress cell proliferation in the high Concentration range. When inflammatory cytokines in the culture supernatant measured by ELISA, not observed in inflammatory synovial cells in comparison normal and synovial membrane cells and inflammatory synovial cells. Inflammatory effect by inducing inflammation due to mechanical stress etc. on normal cells, anti-inflammatory effect in tissues in animal experiments and metabolism of fullerene.