| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Hydroxyapatite (HAp) cement is a clinically applicable bone substitute having excellent osteoconductivity. In this study, we found that surface of HAp cement became carbonate apatite (CAp), a bone-like component, after setting, and thus could be replaced by new bone. Upon this result, we tried to create a new CAp cement, where CAp was formed during setting reaction. Calcium carbonate is one of the powder component in CAp cement, and has three polymorphisms, including calcite and vaterite. Vaterite has larger solubility than calcite. CAp cement containing vaterite showed shorter setting time and greater conversion rate to CAp than that containing calcite. Most importantly, CAp cement showed greater osteoconductivity than that of HAp cement CAp cement having excellent osteoconductivity, bioresorbability, and easy morphogenesis would be expected as a new bone substitute that overcome problems of traditional HAp cement.
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