Evaluation of simulative effect of adrenal steroids secretion by exposure to an extremely-low-frequency magnetic field.
Project/Area Number |
25870475
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Environmental impact assessment
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | The University of Tokushima |
Principal Investigator |
Kitaoka Kazuyoshi 徳島大学, 教養教育院(仮称)設置準備室, 講師 (50432753)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 極低周波変動磁界 / コルチコステロン / アルドステロン / 副腎皮質 / 副腎皮質ホルモン / cAMP / ホスホジエステラーゼ / cAMP |
Outline of Final Research Achievements |
Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices.In the current study, we investigated the effect of ELF-MF exposure on the mouse adrenal cortex-derived Y-1 cell line and the human adrenal cortex-derived H295R cell line to clarify whether the ELF-MF stimulates adrenal steroidogenesis directly. ELF-MF exposure was found to significantly stimulate adrenal steroidogenesis in Y-1 cells, but the effect was weak in H295R cells. Our results suggest that ELF-MF exposure stimulates adrenal steroidogenesis via an increase in intracellular cAMP caused by the inhibition of phosphodiesterase activity in Y-1 cells.
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Report
(4 results)
Research Products
(6 results)