Implication of lectin proteins for pathogensis of mental disorders.

• Project/Area Number: 25870494
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science; Neurochemistry/Neuropharmacology
• Research Institution: Kyushu University
• Principal Investigator: Kajitani Kosuke 九州大学, 基幹教育院, 准教授 (10597272)
• Research Collaborator: Nakabeppu Yusaku
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ガレクチン-1 / ガレクチン-3 / 統合失調症 / マウス / 海馬 / 介在神経 / レクチンタンパク / 血清

Outline of Final Research Achievements

Galectin (gal) is one of several well-studied proteins among the lectin families which are involved in various biological processes.The purpose of this project is to clarify the relationship between gal and mental disorders. In this study, we reported several new findings as follows: 1) 77% of gal-1-positive cells expressed somatostatin and 79% of gal-1-positive cells expressed GAD67 in the mouse hippocampus, 2)We counted the number of somatostatin-, parvalbumin-, and GAD67-positive cells in the hippocampi of both gal-1 knockout and wild-type mice. However, no significant differences were found, 3)The serum galectin-3 levels were significantly higher in patients with schizophrenia than they were in controls, 4), A significant positive correlation was found between the serum galectin-3 level and the positive symptoms score of the Brief Psychiatry Rating Scale.

Research Products

• [Journal Article] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. (2014)
  • Author(s): Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y.N., Kajitani, K., Tsuchimoto, D., Nestler, E.J., and Nakabeppu, Y.
  • Journal Title: Glia Volume: N/A Issue: 8 Pages: 1284-1298
  • DOI: 10.1002/glia.22680
  • Peer Reviewed
• [Journal Article] Characterization of galectin-1-positive cells in the mouse hippocampus. (2014)
  • Author(s): Kajitani, K., Kobayakawa, Y., Nomaru, H., Kadoya, T., Horie, H., and Nakabeppu, Y.
  • Journal Title: Neuroreport Volume: 25 Issue: 3 Pages: 171-176
  • DOI: 10.1097/wnr.0000000000000068
  • Peer Reviewed
• [Journal Article] Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1 transgenic mice. (2014)
  • Author(s): Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J.I., and Nakabeppu, Y.
  • Journal Title: Neuropathol Appl Neurobiol Volume: N/A Issue: 2 Pages: 227-244
  • DOI: 10.1111/nan.12123
  • Peer Reviewed
• [Presentation] Characterization of galectin-1-positive cells in the mouse hippocampus: the relevance of galectin-1 to interneurons. (2015)
  • Author(s): 梶谷康介
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場、神戸国際展示場
  • Year and Date: 2015-07-28