| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Galectin (gal) is one of several well-studied proteins among the lectin families which are involved in various biological processes.The purpose of this project is to clarify the relationship between gal and mental disorders. In this study, we reported several new findings as follows: 1) 77% of gal-1-positive cells expressed somatostatin and 79% of gal-1-positive cells expressed GAD67 in the mouse hippocampus, 2)We counted the number of somatostatin-, parvalbumin-, and GAD67-positive cells in the hippocampi of both gal-1 knockout and wild-type mice. However, no significant differences were found, 3)The serum galectin-3 levels were significantly higher in patients with schizophrenia than they were in controls, 4), A significant positive correlation was found between the serum galectin-3 level and the positive symptoms score of the Brief Psychiatry Rating Scale.
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