Research Project
Grant-in-Aid for Young Scientists (B)
Islet transplantation is a promising therapy for brittle type 1 diabetes. However shortage of donor becomes a problem. Islet cell is vulnerable to stress insulted from islet isolation to transplantation. Therefore the number of islet cell which are alive finally is very few. We hypothesized that islet co-transplantation with pancreas ductal cell that secrete vascular growth factor can protect the islets from oxidative stress induced by ischemia. We also use newly develop technique with PDX1 derived luciferase system (Gluc). We transplanted 300 hundred Gluc islets into subcapsular of kidney or liver. The outcome was not different between the transplantation site. And co-transplantation was not affect the outcome. The co-transplantation is limited to protect islets from the stress. Therefore further innovation is needed for the success of islet transplantation.
All 2016 2015 2014 2013 Other
All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 5 results, Open Access: 4 results) Presentation (3 results)
Transplant Proc
Volume: 48(4) Issue: 4 Pages: 1110-4
10.1016/j.transproceed.2015.12.119
World J Gastroenterol
Volume: 22(34) Issue: 34 Pages: 7851-6
10.3748/wjg.v22.i34.7851
Liver Transplantation
Volume: 21(2) Issue: 2 Pages: 233-238
10.1002/lt.24048
Pancreas
Volume: 43(8) Issue: 8 Pages: 1317-1322
10.1097/mpa.0000000000000184
Endocrinology
Volume: 154 Issue: 11 Pages: 4388-4395
10.1210/en.2012-2248
