| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, to develop the drug/siRNA delivery system to the brain using nasal administration and multifunctional peptide-modified nanocarriers, we designed the novel functional peptide-modified nanocarriers and estimated them about the intracellular siRNA uptake in neuron cells and nose-to-brain delivery of siRNA in rats. The functional peptide-modified nanocarriers strongly increased the intracellular siRNA uptake and siRNA delivery to the brain from nasal cavity. Combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery showed the therapeutic effects in t-MCAO (Transient-Middle Cerebral Artery Occlusion) rats. In conclusion, combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery can be expected as an useful drug delivery system for CNS diseases.
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