Development of the neuron targeting functional peptide-modified nanocarriers for CNS diseases therapy
| Project/Area Number |
25870767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
Physical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳デリバリー / Nose-to-Brain / 機能性ペプチド / 高分子ミセル / ナノキャリア / 核酸デリバリー / 細胞透過性ペプチド / 脳内デリバリー / 脳虚血再灌流障害 / 脳血管障害 / 神経細胞 / DDS / 核酸 / 脳 / 経鼻投与 |
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| Outline of Final Research Achievements |
In this study, to develop the drug/siRNA delivery system to the brain using nasal administration and multifunctional peptide-modified nanocarriers, we designed the novel functional peptide-modified nanocarriers and estimated them about the intracellular siRNA uptake in neuron cells and nose-to-brain delivery of siRNA in rats. The functional peptide-modified nanocarriers strongly increased the intracellular siRNA uptake and siRNA delivery to the brain from nasal cavity. Combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery showed the therapeutic effects in t-MCAO (Transient-Middle Cerebral Artery Occlusion) rats. In conclusion, combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery can be expected as an useful drug delivery system for CNS diseases.
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Report
(4 results)
Research Products
(24 results)
