| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
In this study for ultrasonic drug delivery system, an ex vivo system for measuring sensitivity of targeted microbubbles to target molecular was established. In the system, a quartz crystal microbalance was employed as a sensing device for detecting both target molecular and bubbles. The physical theoretical model for analyzing the number density of specifically absorbing bubbles was proposed. The model-based analysis enabled to evaluate the concentration of streptavidin as target molecular and the number density of biotinylated microbubbles specifically absorbing the streptavidin. The proposed system shows promise for the application as evaluation system of the sensitivity of targeted microbubbles.
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