| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Seven additional independent web-based datasets of lung adenocarcinoma were examined. The expression level of the ASCL1 geneset was used to define the neuroendocrine character based on the method we previously reported. Subtyping was performed by consensus clustering with nonnegative matrix factorization. Correlation of overall survival was analyzed with the Kaplan-Meier method. The neuroendocrine subtype was identified from each of seven independent cohorts. Among them, three datasets showed statistically significant association with patient survival (p < 0.05). Somatic mutations identified in the neuroendocrine subtype with the TCGA data were common ones such as TP53, STK11 and KRAS. Transcriptomic profiling partially reproduced the neuroendocrine subtype in lung adenocarcinoma samples derived from the independent datasets.
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