Functional acquirement of long noncoding RNA is regulated by alternative 3' end processing
| Project/Area Number |
25871195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
Molecular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 非コードRNA / RNA結合タンパク質 / 選択的3'末端プロセシング / 長鎖非コードRNA / 脱ユビキチン化酵素 / 翻訳後修飾 |
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| Outline of Final Research Achievements |
To be aimed at elucidating the production mechanism of diverse functions of lncRNA, we explored how the alternative 3’ end processing of NEAT1 lncRNA is acted and regulated. HNRNPK, which is a factor of the alternative 3’ end processing of NEAT1 lncRNA, was focused and we discovered the multiple interaction factors that modulate the function for the processing of HNRNPK. In addition, we showed the great potential that the alternative 3’ end processing of NEAT1 lncRNA was modulated by JNK pathway, which is one of MAPK pathways.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] NEAT1 long noncoding RNA regulates transcription via protein sequestration within2014
Author(s)
Hirose T, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, Yokoi T, Nakagawa S, Bénard M, Fox AH, Pierron G.
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Journal Title
Mol Biol Cell.
Volume: 25
Issue: 1
Pages: 169-183
DOI
Related Report
Peer Reviewed
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