A study on the role of the spleen in liver carcinogenesis

• Project/Area Number: 25893156
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: SAITO Yu 徳島大学, ヘルスバイオサイエンス研究部, 助教 (50548675)
• Research Collaborator: IMURA Satoru 徳島大学, 病院, 特任教授 (90380021) ; MORINE Yuji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (60398021) ; IKEMOTO Tetsuya 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20398019)
• Project Period (FY): 2013-08-30 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肝細胞癌 / 脾摘 / HGF / c-Met / 火摘

Outline of Final Research Achievements

In Cirrhotic patients, the expressions of TGF-β1 derived from splenic macrophage in were significantly higher than those in normal liver patients. In addition, the splenic IL6, TNF-a, and MCP-1 expressions were lower and HGF expressions were higher. In the patients with splenectomy accompanied with liver cancer, the splenic IL-6, HGF and IL-8 expressions were significantly higher than those in the patients with splenectomy accompanied without liver cancer. Hepatic c-Met, the receptor of HGF, expression were also higher.
The relationship between spleen and liver had a critical role in liver fibrosis and carcinogenesis.

Research Products

• [Journal Article] Cytokine expression in spleen affects progression of liver cirrhosis through liver-spleen cross-talk (2014)
  • Author(s): Asanoma M, Ikemoto T, Mori H, Utsunomiya T, Imura S, Morine Y, Iwahashi S, Saito Y, Yamada S, Shimada M
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 12 Pages: 1217-1223
  • DOI: 10.1111/hepr.12267
  • Peer Reviewed
• [Journal Article] Homing effect of adipose-derived stem cells to the injured liver: the shift of stromal cell-derived factor 1 expressions. (2014)
  • Author(s): Saito Y1, Shimada M, Utsunomiya T, Ikemoto T, Yamada S, Morine Y, Imura S, Mori H, Arakawa Y, Kanamoto M, Iwahashi S, Takasu C.
  • Journal Title: Journal of Hepatobiliary Pancreat Science Volume: 21 Issue: 12 Pages: 873-880
  • DOI: 10.1002/jhbp.147
  • Peer Reviewed
• [Journal Article] Beneficial effects of green tea catechin on massive hepatectomy model in rats (2014)
  • Author(s): Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M
  • Journal Title: J Gastroenterol Volume: 49(4) Issue: 4 Pages: 692-701
  • DOI: 10.1007/s00535-013-0799-9
  • Peer Reviewed
• [Presentation] 肝細胞癌におけるLine1 methylation statusは予後因子となる (2014)
  • Author(s): 齋藤裕, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 高須千絵
  • Organizer: 第69日本消化器外科学会
  • Place of Presentation: 郡山総合体育館(福島県郡山市)
  • Year and Date: 2014-07-16 – 2014-07-18
• [Presentation] 80歳以上超高齢者における肝切除の妥当性に関する検討-術前栄養評価から見た高齢者の特徴- (2014)
  • Author(s): 齋藤裕, 島田光生, 宇都宮徹, 居村暁, 森根裕二, 池本哲也, 荒川悠佑, 金本真美, 岩橋衆一, 山田眞一郎, 石川大地
  • Organizer: 第26日本肝胆膵外科学会学術集会
  • Place of Presentation: 和歌山県民文化会館(和歌山県和歌山市)
  • Year and Date: 2014-06-11 – 2014-06-13
• [Presentation] 脂肪由来幹細胞の細胞保護効果には臓器特異性がある (2014)
  • Author(s): 斎藤裕, 島田光生, 宇都宮徹, 石川大地, 山田眞一郎, 高須千絵, 岩橋衆一, 金本真美, 荒川悠佑, 森大樹, 池本哲也, 森根裕二
  • Organizer: 第114回 日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2014-04-03 – 2014-04-05