| Project/Area Number |
25893156
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAITO Yu 徳島大学, ヘルスバイオサイエンス研究部, 助教 (50548675)
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| Research Collaborator |
IMURA Satoru 徳島大学, 病院, 特任教授 (90380021)
MORINE Yuji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (60398021)
IKEMOTO Tetsuya 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20398019)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肝細胞癌 / 脾摘 / HGF / c-Met / 火摘 |
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| Outline of Final Research Achievements |
In Cirrhotic patients, the expressions of TGF-β1 derived from splenic macrophage in were significantly higher than those in normal liver patients. In addition, the splenic IL6, TNF-a, and MCP-1 expressions were lower and HGF expressions were higher. In the patients with splenectomy accompanied with liver cancer, the splenic IL-6, HGF and IL-8 expressions were significantly higher than those in the patients with splenectomy accompanied without liver cancer. Hepatic c-Met, the receptor of HGF, expression were also higher.
The relationship between spleen and liver had a critical role in liver fibrosis and carcinogenesis.
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