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To develope a novel screening method of histone deacetylase (HDAC) inhibitor having anticancer activity

Research Project

Project/Area Number 25893215
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

FUJII SEIKO  九州歯科大学, 歯学部, 助教 (80714659)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsHDAC阻害剤 / 口腔癌 / テロメラ―ゼ / HDAC / テロメラーゼ / 癌
Outline of Final Research Achievements

Epigenetic modifications such as histone deacetylation are commonly related to tumor development and histone deacetylase (HDAC) inhibitors have been shown to be potential drugs for cancer treatment. Ky-2 is a novel HDAC inhibitor produced by a combination of the HDAC inhibitors TSA and TPX.
In the present study, we investigated the effectiveness of Ky-2 to induce cell cycle and apoptosis in oral squamous carcinoma cells. In addition, we examined the signaling pathway related to the cell cycle and apoptosis in Ky-2-treated oral squamous carcinoma cells.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

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