Establishment of novel periodontal tissue regeneration using mesenchymal stem cells with high osteodifferentiation capacity
| Project/Area Number |
25893221
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Kansai Medical University (2014)
Iwate Medical University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MSC / サイトカイン / 歯周病 / IL-1 / IL-6 / 再生医学 / 間葉系幹細胞 / トランスフェクション / インターロイキン / 再生医療 |
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| Outline of Final Research Achievements |
Chronic periodontitis is an intraoral infectious disease that affects the nation with high prevalence. We see a lot of patients being forced to extract their teeth because of inflammatory bone resorption. To promote fundamental research of novel cell therapy using mesencymal stem cells, we established stem cell lines from the bone marrow of GFP transgenic mice and constructed a new expression vector targeting inhibition of several inflammatory cytokines. We expect that those new tools promote novel cell therapy in periodontal research.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells.2014
Author(s)
Aomatsu, E., Takahashi, N., Sawada, S., Okubo, N., Hasegawa, T., Taira, M., Miura, H., Ishisaki, A., and Chosa, N.
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Journal Title
Sci. Rep.
Volume: 4
Issue: 1
Pages: 3652-3652
DOI
Related Report
Peer Reviewed / Open Access
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