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Study of radiotherapy to selectively treat only malignant tumor cells with nano particle including boron

Research Project

Project/Area Number 25893226
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurosurgery
Research InstitutionInternational University of Health and Welfare

Principal Investigator

SHIRAKAWA Makoto  国際医療福祉大学, 薬学部, 助教 (40707759)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsホウ素中性子補足療法 / リポソーム / 中性子捕捉療法
Outline of Final Research Achievements

As a low invasive treatment for the malignant tumors, boron neutron capture therapy is featured. This study focused on membrane permeability peptide (TAT) and developed the new carrier that is able to deliver the high concentration boron in the tumor cell.
We prepared liposome using the boron peptide lipid analog which already succeeded in development. And the liposome were evaluated the physical property or ability of introduction into cell or cytotoxicity reaction by neutron irradiation.
The liposome which prepared at approximately 100nm succeeded in the introduction of high concentration boron into tumor cell by TAT peptide analog. So, we administered the liposome to tumor cell, and irradiated neutron beam. As a result, the liposome significantly showed cytotoxicity reaction in comparison with each control group. And the survival rate of tumor cell became less than 1%.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report

Research Products

(5 results)

All 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Evaluation of boron content liposome modified protein-transduction domains for boron neutron capture therapy.2014

    • Author(s)
      Makoto Shirakawa, Kei Nakai, Fumiyo Yoshida, A. Zoboronok, Tetsuya Yamamoto, Akira Matsumura.
    • Journal Title

      Journal of Emerging Technology and Advanced Engineering

      Volume: 4 Pages: 74-79

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 悪性腫瘍に対する抗がん剤封入新規リポソームの評価2015

    • Author(s)
      伊藤隆宏, 佐藤美里, 白川真
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法 (BNCT)応用を見据えた腫瘍親和性ペプチド修飾リポソームの開発2014

    • Author(s)
      白川真
    • Organizer
      第4回国際医療福祉大学学会学術大会
    • Place of Presentation
      栃木県大田原市
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Boron Neutron Capture Therapy (BNCT) for liposomal Drug Delivery System by passive targeting.2013

    • Author(s)
      M. Shirakawa
    • Organizer
      7th Young Researcher's Boron Neutron Capture Therapy meeting
    • Place of Presentation
      GRANADA,SPAIN
    • Related Report
      2013 Annual Research Report
  • [Presentation] PEG化ホウ素化合物による中性子捕捉療法2013

    • Author(s)
      白川 真
    • Organizer
      第10回日本中性子捕捉療法学会
    • Place of Presentation
      岡山,日本
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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