• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The evaluation of the promotion of secondary dentin by controlling release of simvastatin

Research Project

Project/Area Number 25893264
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

MIYAZAWA Atsuko  日本歯科大学, 生命歯学部, 助教 (00706997)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords徐放 / シンバスタチン / 歯髄細胞 / 象牙芽細胞 / 硬組織再生 / 徐放性 / 分解性 / 象牙芽細胞分化 / 象牙質再生 / ゼラチンハイドロゲル / 薬物徐放 / 象牙質
Outline of Final Research Achievements

Simvastatin (ST) was incorporated into the micelles of gelatin grafted with L-lactic acid oligomers (LAo) to allow water-solubilization. The simvastatin-LAo-grafted gelatin (LAo-g-gelatin) micelles were mixed with gelatin, followed by chemical crosslinking to form gelatin hydrogels (ST Mi/GH). The ST Mi were released from the gelatin hydrogel granules (GH) through enzymatic degradation. From the in vitro experiments, the most effective ST Mi/GH for odontoblastic differentiation was that of 2 weeks degradation. In addition, the ST in the micelle form exhibited biological activities to induce ALP activity, calcium deposition and BMP-2 production in vitro. Now the in vivo experiments are evaluated. The quality and quantity of dentin tissue formed should be evaluatedusing dental pulp capping models and comparing with those of other pulp-capping materials.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (3 results)

All 2014

All Presentation (3 results)

  • [Presentation] Development of the HA composite for the prevention of BRONJ2014

    • Author(s)
      宮澤敦子
    • Organizer
      2014 ANNUAL MEETING
    • Place of Presentation
      Hawaii Convention Center(Honolulu, Hawaii, United states of America)
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] BRONJ予防ためのHA複合体の開発2014

    • Author(s)
      宮澤敦子
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-01 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] BROMJを予防するためのHA複合体の開発2014

    • Author(s)
      宮澤敦子
    • Organizer
      第34回日本歯科薬物療法学会
    • Place of Presentation
      大阪歯科大学(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi