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The effect of a novel porous scaffold with a three-dimensional network structure on osteoconductivity and handleability

Research Project

Project/Area Number 25893284
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

ARAHIRA Takaaki  福岡歯科大学, 歯学部, 助教 (30706958)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsScaffold / β-TCP / ポリ乳酸 / 骨再生 / 力学特性 / 幹細胞 / PLLA / 多孔質構造 / 多孔質足場材 / 生分解性高分子 / 生体活性セラミックス
Outline of Final Research Achievements

In the field of bone regenerative medicine, the need for artificial bone substitutes has been rapidly increasing, and various porous bioactive ceramics have been developed for use as bone substitutes. While materials such as β-tricalcium phosphate (β-TCP) have good oseteoconductivity, poly (L-lactide acid) (PLLA) has been shown to have good mechanical and physical properties. Therefore, the primary aim of this study was to fabricate a porous β-TCP scaffold with a PLLA network structure (β-TCP/PLLA) for use in bone tissue engineering. It was found that β-TCP/PLLA scaffold improved good mechanical property and cell affinity.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Development and characterization of a novel porous β-TCP scaffold with a three-dimensional PLLA network structure for use in bone tissue engineering2015

    • Author(s)
      T. Arahira, M. Maruta, M. Matsuya, M. Todo
    • Journal Title

      Materials Letters

      Volume: 152 Pages: 148-150

    • DOI

      10.1016/j.matlet.2015.03.128

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 骨再生のためのβ-TCP/PLLA複合系骨補填材の創製2015

    • Author(s)
      荒平高章,丸田道人, 松家茂樹,東藤貢
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨再生のための新規βリン酸三カルシウム/ポリ乳酸複合系scaffoldの作製と評価2015

    • Author(s)
      荒平高章,丸田道人, 松家茂樹,東藤貢
    • Organizer
      日本機械学会第27回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨再生のための新規β-TCP/PLLA複合系scaffoldの創製2014

    • Author(s)
      荒平高章,丸田道人, 松家茂樹
    • Organizer
      平成26年度秋期第64回日本歯科理工学会学術講演会
    • Place of Presentation
      広島
    • Year and Date
      2014-10-04 – 2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 操作性・骨伝導性に優れるβ-TCP/PLLA複合系scaffoldの作製と基礎的評価2014

    • Author(s)
      荒平高章,丸田道人, 松家茂樹,東藤貢
    • Organizer
      第25回バイオフロンティア講演会
    • Place of Presentation
      鳥取
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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