Protection against MRSA infection using conserved antigen among Gram-positive bacterial cell surface
Project/Area Number |
25893286
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Environmental and hygienic pharmacy
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Research Institution | Nagasaki International University |
Principal Investigator |
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Research Collaborator |
LEE Bok LEUL 釜山大学校, 薬学部, 教授
TAKAHASHI Kazue Harvard Medical School, Massachusetts General Hospital, Assistant Professor
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Project Period (FY) |
2013-08-30 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 細菌宿主相互作用 / 免疫賦活化 / 細胞壁タイコ酸 / 黄色ブドウ球菌 / 韓国:米国:ドイツ / 国際情報交換 / 韓国 / アメリカ合衆国 / ドイツ |
Outline of Final Research Achievements |
Antibodies against wall teichoic acids (WTA) have major roles to protect against methicillin-resistant Staphylococcus aureus (MRSA) infection. Because WTA is well distributed among GC-low content Gram-positive bacteria, we hypothesize if anti-S. aureus WTA antibodies may be induced by non-pathogenic bacteria. Here, we found that a lactic acid producing bacterium belong to Lactobacillus species had an antigen recognized by anti-S. aureus WTA antibodies. This is a candidate non-pathogenic strain that may induce anti-MRSA antibodies.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Glycoepitopes of staphylococcal wall teichoic acid govern complement-mediated opsonophagocytosis via human serum antibody and mannose-binding lectin.2013
Author(s)
Kurokawa K, Jung DJ, An JH, Fuchs K, Jeon YJ, Kim NH, Li X, Tateishi K, Park JA, Xia G, Matsushita M, Takhashi K, Park HJ, Peschel A, and Lee BL.
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Journal Title
J. Biol. Chem.
Volume: 288
Issue: 43
Pages: 30956-30968
DOI
Related Report
Peer Reviewed
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[Presentation] Novel staphylococcal wall teichoic acid (WTA)-derivative shows protective effects against USA300 MRSA infection in a murine model.2014
Author(s)
Khan A, Lee MJ, Lee JH, Seong MY, Kurokawa K, Takahashi K, Ahn DH, Peschel A, and Lee BL.
Organizer
The 16th International Symposium on Staphylococci and Staphylococcal Infections.
Place of Presentation
Chicago, IL, USA
Year and Date
2014-08-26 – 2014-08-29
Related Report
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[Presentation] tarS-harboring Staphylococcus aureus strains are opsonophagocytosed by human anti-wall teichoic acid-IgG.2014
Author(s)
Kim NH, Lee JH, Winstel V, Kurokawa K, An JH, Khan A, Seong MY, Lee MJ, Peschel A, and Lee BL.
Organizer
The 16th International Symposium on Staphylococci and Staphylococcal Infections.
Place of Presentation
Chicago, IL, USA
Year and Date
2014-08-26 – 2014-08-29
Related Report
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