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Chemical dissection of mitochondrial function and inflammasome activation

Research Project

Project/Area Number 25893288
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pharmacology in pharmacy
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

KITAMI Toshimori  独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (70708594)

Project Period (FY) 2013-08-30 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsミトコンドリア / 化合物 / 代謝
Research Abstract

Recent studies have highlighted the role of mitochondrial reactive oxygen species in innate immune response (in particular of NLRP3 inflammasome activation). Identifying clinically used drugs that have impact on mitochondrial reactive oxygen species in innate immune cells (such as macrophage) will be useful for understanding the role of mitochondria in inflammation as well as identifying new drug toxicity and therapeutic use. We took advantage of our previous mitochondrial chemical screening compendium and identified a unique compound that induced strong inflammatory response. We are currently pursuing the mechanism of action of this drug to understand the relationship between mitochondria and inflammation.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (1 results)

All Other

All Remarks (1 results)

  • [Remarks]

    • URL

      http://www.ims.riken.jp/labo/47/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-09-12   Modified: 2016-11-25  

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