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Potential anticancer effect by inhibiting NFBD1/MDC1

Research Project

Project/Area Number 25893292
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionChiba Cancer Center (Research Institute)

Principal Investigator

ANDO KIYOHIRO  千葉県がんセンター(研究所), がん治療開発グループ, 客員研究員 (10455389)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsNFBD1 / MDC1 / PLK1 / topoisomerase / decatenation checkpoint / neuroblastoma / CHK1 / TP53 / 癌 / 遺伝子 / キナーゼ阻害 / アポトーシス / TOPOIIalpha / ICRF-193
Outline of Final Research Achievements

It has been reported that functional inhibition of NFBD1/MDC1 potentiates anticancer effect. However, the molecular mechanism and biomarker that predicts its sensitivity have been still unclear. In this study, we clarified that NFBD1 is phosphorylated by PLK1 and allows cell to enter mitosis by recovering decatenation checkpoint that is mediated a physical interaction of NFBD1 and TOPOIIα. These results indicated that the precocious M phase entry by inhibiting NFBD1 might increase sensitivity of a genotoxic agent and radiation. Furthermore, our microarray analysis suggested that possible candidates of biomarker related to the sensitivity were TP53 and its downstream genes.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report

Research Products

(3 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] NFBD1/MDC1 is phosphorylated by PLK1 and controls G2/M transition through the regulation of a TOPOIIα-mediated decatenation checkpoint.2013

    • Author(s)
      Ando K, Ozaki T, Hirota T, Nakagawara A.
    • Journal Title

      PLoS One.

      Volume: e82744 Pages: 0-0

    • DOI

      10.1371/journal.pone.0082744

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] CHK1阻害剤はMYCN増幅神経芽腫のp53非依存的アポトーシスを誘導する2014

    • Author(s)
      安藤清宏、佐藤勉、小林修三
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] NFBD1/MDC1 はPlk1 によるリン酸化を介してDecatenation Checkpoint に関連したG2/M 期進行を制御する

    • Author(s)
      安藤清宏
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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