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A trial of artificial ovary formation by cell sheet engineering

Research Project

Project/Area Number 25893298
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionOkayama University

Principal Investigator

TAKAYAMA Osamu  岡山大学, 学内共同利用施設等, 助教 (80650879)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生殖補助医療 / 卵胞培養 / 産婦人科科学 / 発生工学 / 細胞シート / 不妊治療 / 産婦人科学
Outline of Final Research Achievements

Recently, it has been reported that cancer patients could pregnant by transplantation of cryopreserved ovarian tissue following chemo- or radiation-therapy. However, this method may have a risk of re-introduction cancer cells to the patient after medical treatment. Although this risk may be avoided by using in vitro embryo production techniques following in vitro growth of follicular oocytes, it is difficult to grow oocytes from early pre-antral follicles, especially earlier than secondary follicles. Current study was undertaken to find a possibility of in vitro growth of human early pre-antral follicles by cell sheet engineering.
Our data show that human early primary follicles can grow in vitro, but the follicular development stops until 1 week after the start of culture. Further studies are required to find more suitable culture conditions for follicular survival.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report

Research Products

(3 results)

All 2014

All Presentation (3 results)

  • [Presentation] ヒト初期卵胞の体外培養(IVG)における培養条件の検討2014

    • Author(s)
      髙山修、本橋秀之、奥平裕一、李 楊、Pilar Ferre、Rukmali Athurupana、中塚幹也、 舟橋弘晃
    • Organizer
      第59回日本生殖医学会学術講演会
    • Place of Presentation
      京王プラザホテル, 新宿区, 東京
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] In vitro development of human early pre-antral follicles within alginate hydrogels2014

    • Author(s)
      Takayama O, Motohashi H.H, Okudaira Y, Li Y, Ferre P, Athurupana R, Nakatsuka M and Funahashi H.
    • Organizer
      Ovarian Club IV
    • Place of Presentation
      Novotel Tour Eiffel Hotel Paris, France
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト初期1次卵胞の体外培養の試み2014

    • Author(s)
      髙山修、本橋秀之、中塚幹也、 舟橋弘晃
    • Organizer
      第13回生殖バイオロジー東京シンポジウム
    • Place of Presentation
      都市センターホテル, 千代田区, 日本
    • Year and Date
      2014-07-27
    • Related Report
      2014 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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