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Prevention and treatment for sensorineural hearing loss by controlling the system of innate immunity

Research Project

Project/Area Number 25893299
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research Institution独立行政法人国立病院機構(東京医療センター臨床研究センター)

Principal Investigator

HAYASHI Yushi  独立行政法人国立病院機構(東京医療センター臨床研究センター), 政策医療企画研究部, 医師 (40715166)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords蝸牛 / 自然免疫 / 有毛細胞 / 支持細胞 / 感音難聴 / ウイルス感染 / I型IFN / RIG-I family / I型IFN
Outline of Final Research Achievements

We analyzed the mechanism of sensorineural hearing loss caused by viral infection such as sudden hearing loss, Meniere's disease and congenital hearing loss using ex vivo system of cochlear sensory epithelia. To investigate the influence of type I interferon (IFN) which is transcribed in supporting cells during viral infection on the cochlear sensory epithelium, we used IFNAR1 which is a receptor of type I IFN knock out mice.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report

Research Products

(9 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Insulin-like growth factor 1 induces the transcription of Gap43 and Ntn1 during hair cell protection in the neonatal murine cochlea.2014

    • Author(s)
      Hayashi Y, Yamamoto N, Nakagawa T, Ito J.
    • Journal Title

      Neurosci Lett.

      Volume: 560 Pages: 7-11

    • DOI

      10.1016/j.neulet.2013.11.062.

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice.2013

    • Author(s)
      Hayashi Y, Yamamoto N, Nakagawa T, Ito J.
    • Journal Title

      Mol Cell Neurosci.

      Volume: 56 Pages: 29-38

    • DOI

      10.1016/j.mcn.2013.03.003.

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.2013

    • Author(s)
      Hayashi Y, Onomoto K, Narita R, Yoneyama M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T.
    • Journal Title

      Microbes Infect.

      Volume: 15 Pages: 592-598

    • DOI

      10.1016/j.micinf.2013.04.008.

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Pathogenesis of Sensorineural Hearing Loss During Virus Infection of the Cochlear Sensory Epithelium2015

    • Author(s)
      Yushi Hayashi, Koji Onomoto, Mitsutoshi Yoneyama, Kimitaka Kaga, Takashi Fujita, Nobuyuki Tanaka
    • Organizer
      38th Association for Research in Otolaryngology MidWinter Meeting
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2015-02-21 – 2015-02-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Type I IFN is produced in supporting cells against virus infection of the cochlear sensory epithelium via RIG-I like receptor signaling pathway.2014

    • Author(s)
      Hayashi Y, Onomoto K, Narita R, Yoneyama M, Kato H, Taura A, Nakagawa T, Ito J, Fujita T, Kaga K.
    • Organizer
      ARO 37th MidWinter Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      20140222-20140226
    • Related Report
      2013 Annual Research Report
  • [Presentation] Type I IFN is produced in supporting cells against virus infection of the cochlear sensory epithelium via RIG-I like receptor signaling pathway2014

    • Author(s)
      Yushi Hayashi, Koji Onomoto, Ryo Narita, Mitsutoshi Yoneyama, Hiroki Kato, Akiko Taura, Takayuki Nakagawa, Juichi Ito, Kimitaka Kaga, Takashi Fujita
    • Organizer
      Inner Ear Biology 2014 in Kyoto
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-11-01 – 2014-11-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Type I IFN is produced in supporting cells against virus infection of the cochlear sensory epithelium via RIG-I like receptor signaling pathway2014

    • Author(s)
      Yushi Hayashi, Koji Onomoto, Ryo Narita, Mitsutoshi Yoneyama, Hiroki Kato, Akiko Taura, Takayuki Nakagawa, Juichi Ito, Kimitaka Kaga, Takashi Fujita
    • Organizer
      51st Inner Ear Biology Workshop
    • Place of Presentation
      Sheffield, UK
    • Year and Date
      2014-08-30 – 2014-09-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全身III度の熱傷に対する加療で薬剤性に両耳聾となり、人工内耳埋め込み手術を実施するに至った成人の1例2013

    • Author(s)
      林 裕史、竹腰英樹、加我君孝
    • Organizer
      第23回日本耳科学会総会
    • Place of Presentation
      宮崎市
    • Year and Date
      20131124-20131126
    • Related Report
      2013 Annual Research Report
  • [Book] Microtia and Atretia. Temporal bone computed tomography of patients with poor postoperative hearing improvement after surgery for atresia of the external auditory canal.2014

    • Author(s)
      Hayashi Y, Kaga K.
    • Total Pages
      4
    • Publisher
      Karger
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-09-12   Modified: 2019-07-29  

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