Promotion of in vivo autologous tissue formation by light emitting diode: Application to development of Stent Biovalve
| Project/Area Number |
25893303
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cardiovascular surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
FUNAYAMA Marina 独立行政法人国立循環器病研究センター, 研究開発基盤センター, 研究員 (30713599)
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| Project Period (FY) |
2013-08-30 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 心臓代替弁 / 肺動脈弁 / 心血管疾患 / 医療 / 心臓血管外科 / 光刺激 / 組織工学 |
|---|
| Outline of Final Research Achievements |
Surgical valve replacement is an efficacious treatment for patients with cardiovascular disease, however the artificial heart valves have limitations regarding their durability. The in-body tissue architecture (IBTA) technology is a novel technique based on the tissue encapsulation phenomenon. Using this technology, autologous self-expanding valved stent, named Stent Biovalve, could be made simple and safe. However, the limited leaflet formation through the tissue migration was a serious problem. To solve this limitation, we have firstly established an effect on IBTA of the light radiation. Secondly, we evaluated directly and non-invasively the formation process of the leaflet tissues inside the mold. Moreover, we designed novel molds to activate leaflet formation. Finally, Stent Biovalve showed favorable hemodynamic results in pulmonary valve in beagles. Taken together, the novel method may improve a development of the functional Stent Biovalve.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Successful implantation of autologous valved conduits with self-expanding stent (stent-biovalve) within the pulmonary artery in beagle dogs2015
Author(s)
Funayama M, Matsui Y, Tajikawa T, Sasagawa T, Saito Y, Sagishima S, Mizuno T, Mizuno M, Harada K, Uchida S, Shinoda A, Iwai R, Nakayama Y, Uechi M.
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Journal Title
J Vet Cardiol
Volume: 17(1)
Pages: 54-61
DOI
Related Report
Peer Reviewed
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[Presentation] Establishment of Experimental Animal Models Suitable for Feasibility Testing in the Development of Covered Stent for Intracranial Aneurysms2014
Author(s)
T.Satow, Y.Nakayama, E Hamano, T Mizuno, M.Funayama, D Ishii, M Hayashi, T Moriwaki, H Kawajiri, S Nishi
Organizer
ASNR 52nd Annual Meeting & The Foundation of the ASNR Symposium 2014
Place of Presentation
Montreal, Canada
Year and Date
2014-05-17 – 2014-05-22
Related Report
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[Presentation] Successful 1-device treatment of intracranial giant and/or wide neck aneursyms: 3 essential in vivo experimental designs for pre-clinical evaluation2014
Author(s)
Y.Nakayama, T.Satow, E.Hamano, T.Mizuno, M.Funayama, D.Ishii, M.Hayashi, T.Moriwaki, H.Kawajiri, K.Ihara
Organizer
63th International Congress of the European Society for Cardiovascular and Endovascular Surgery
Place of Presentation
Nice, France
Year and Date
2014-04-24 – 2014-04-27
Related Report
