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EVALUATION OF PERINIDAL CEREBRAL BLOOD FLOW AND METABOLISM USING A NOVEL QUANTITATIVE 15O-PET METHOD IN PATIENTS WITH ARTERIOVENOUS MALFORMATION

Research Project

Project/Area Number 25893304
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurosurgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

MARUYAMA DAISUKE  独立行政法人国立循環器病研究センター, 病院, 医師 (70713840)

Project Period (FY) 2013-08-30 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脳動静脈奇形 / 脳循環代謝 / 15O標識ガス吸入PET / 脳神経疾患 / 機能的賦活
Outline of Final Research Achievements

Assuming a fixed fractionation may introduce systematic errors when imaging pathologic tissues, such as in patients with arteriovenous malformation (AVM), a disorder often characterized by increased arterial blood volume. In AVM patients, we compared the quantitative values of 15O-PET parameters derived using the present a dual-tracer basis function method (DBFM), which avoid the need to assume a fixed fractionation of blood volume as being arterial and venous, and those derived using the previously proposed dual-tracer autoradiography (DARG) methods.
We observed a higher positive correlation between the DBFM method and DARG method in remote ROI than in perinidal ROI.In perinidal ROI, quantitative values of rCBF and rCMRO2 tended to be overestimated more when using DARG than when using DBFM.Our findings demonstrate the validity of the present DBFM method as a possible way to more accurately evaluate perinidal regions in AVM patients.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report

Research Products

(6 results)

All 2015 2014 2013

All Journal Article (1 results) Presentation (5 results)

  • [Journal Article] 15O標識ガス吸入PETを用いた脳動静脈奇形における新たな循環代謝評価の可能性2015

    • Author(s)
      丸山大輔、中川原譲二、飯田秀博、越野一博、森田奈緒美、安部倉友、濱野栄佳、佐藤徹、片岡大治、飯原弘二、髙橋淳
    • Journal Title

      The 33rd Meeting of the Mt. Fuji Workshop on CVD 「脳卒中における脳循環代謝画像のすべてー初心者からエキスパートまでー」

      Volume: 33

    • Related Report
      2014 Annual Research Report
  • [Presentation] EVALUATION OF PERINIDAL CEREBRAL BLOOD FLOW AND METABOLISM USING A NOVEL QUANTITATIVE 15O-PET METHOD IN PATIENTS WITH ARTERIOVENOUS MALFORMATION2015

    • Author(s)
      Daisuke Maruyama, Jyoji Nakagawara, Hidehiro Iida, Kazuhiro Koshino, Naomi Morita, Tetsu Satow, Hiroharu Kataoka, Koji Iihara, Jun Takahashi
    • Organizer
      Brain 2015
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2015-06-27 – 2015-06-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳動静脈奇形における15O 標識ガス吸入PETを用いた新たな循環代謝評価についての検討2015

    • Author(s)
      丸山 大輔, 中川原 譲 , 飯田 秀博 , 越野 一博, 森田 奈緒美, 佐藤 徹, 片岡 大治 , 飯原 弘二, 高橋 淳
    • Organizer
      脳卒中の外科学会総会
    • Place of Presentation
      広島
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 15O標識ガス吸入PETを用いた 脳動静脈奇形における 新たな循環代謝評価の可能性2014

    • Author(s)
      丸山 大輔, 中川原 譲二, 飯田 秀博, 越野 一博, 森田 奈緒美,安部倉 友, 濱野 栄佳 , 佐藤 徹 , 片岡 大治 , 飯原 弘二, 高橋 淳
    • Organizer
      第26回 日本脳循環代謝学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 15O標識ガス吸入PETを用いた 脳動静脈奇形における 新たな循環代謝評価の可能性2014

    • Author(s)
      丸山 大輔, 中川原 譲二 , 飯田 秀博 , 越野 一博 , 安部倉 友, 濱野 栄佳 , 佐藤 徹 , 片岡 大治 , 飯原 弘二, 高橋 淳
    • Organizer
      Mt. Fuji Workshop on CVD
    • Place of Presentation
      盛岡
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] もやもや病における123I-IMP SPECTと15O標識ガス吸入PETによる代償能評価2013

    • Author(s)
      丸山大輔、中川原譲二、森田奈緒美、堀祐樹、飯田秀博、山内圭太、石井大造、小林紀方、森田健一、佐藤徹、片岡大治、飯原弘二
    • Organizer
      第25回日本脳循環代謝学会総会
    • Place of Presentation
      京王プラザホテル札幌(北海道)
    • Related Report
      2013 Annual Research Report

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Published: 2013-09-12   Modified: 2019-07-29  

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