|Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|Outline of Final Research Achievements
In this research, I designed and developed nucleic acid analogues for minimizing the loss of entropy with the formation of nucleic acid complexes. I firstly attempted to develop a highly constrained nucleic acid analogue based on a norbornane structure. As a result, I synthesized an important intermediate for the construction of norbornane structure. However, It was difficult to proceed with further derivatization. Therefore, I newly designed a nucleic acid analogue based on oxi-norbornane structure. I successfully introduced a nucleobase and further derivatization is now proceeding.