Integrated spacial proteomic analysis of Antibody regulation

• Project/Area Number: 25K02509
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: The University of Osaka
• Principal Investigator: ウィング ジェイムス 大阪大学, 感染症総合教育研究拠点, 准教授 (00648694)
• Co-Investigator(Kenkyū-buntansha): 坂口 志文 大阪大学, 免疫学フロンティア研究センター, 特任教授(常勤) (30280770) ; 田中 晃司 大阪大学, 大学院医学系研究科, 助教 (70621019)
• Project Period (FY): 2025-04-01 – 2030-03-31
• Project Status: Granted (Fiscal Year 2025)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2029: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2028: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2027: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2026: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2025: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: Imaging Mass Cytometry / mRNA vaccines / B-cells / Regulatory T-cells

Outline of Research at the Start

We will develop a new method combining spatial imaging and single cell technologies to see both what immune cells are doing and where they are located. This will help us better understand how vaccines work and how the body defends itself against infections, potentially leading to improved vaccines and treatments.